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KMID : 1134820200490010001
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 1 p.1 ~ p.10
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Effects of Garlic and Yuza (Citrus junos) Extracts on Blood Glucose Lowering and Lipid Improvement in Streptozotocin-Induced Diabetic Rats
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Kang-Jae-Ran
Kang Min-Jung
Kim Dong-Gyu
Shin Jung-Hye
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Abstract
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This study examined the effects of garlic (Allium sativum L.) and yuza (Citrus junos) extract on blood glucose lowering and lipid improvement in streptozotocin-induced diabetic rats. As a result of an oral glucose tolerance test, the blood glucose level of the GFD (garlic water extract feed diabetic) group and CFD (yuza water extract feed diabetic) group decreased more rapidly to the fasting glucose level than the DC (diabetic control) group. The blood glucose of the DC group remained constant during the experiment period, whereas the GFD and CFD groups decreased gradually. The serum and liver-tissue lipid contents were lower in the GFD and CFD groups than the DC group. In the liver function indices, the ALP activities of the GFD and CFD groups were significantly lower than the DC group. The AST activity of the GFD group was lower than that of the DC and CFD groups. The BUN and LDH activities, which are a kidney function index, were significantly lower in the GFD and CFD groups than the DC group. The TBARS contents of the serum and liver tissue were significantly higher in the order DC> GFD and CFD> NC. The antioxidant activity of the serum was significantly higher in the GFD and CFD groups than the DC group, but the activity of liver tissues was similar in all the experimental groups. These results suggest that the administration of garlic and yuza water extracts to diabetic rats effectively reduces the blood glucose level. In addition, garlic and yuza water extracts help reduce the body lipid level.
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KEYWORD
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garlic, yuza, diabetes, blood glucose, body lipid
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